[HTML][HTML] A new functional role of the fibrinogen RGD motif as the molecular switch that selectively triggers integrin αIIbβ3-dependent RhoA activation during cell …
A Salsmann, E Schaffner-Reckinger, F Kabile… - Journal of Biological …, 2005 - ASBMB
A number of RGD-type integrins rely on a synergistic site in addition to the canonical RGD
site for ligand binding and signaling, although it is still unclear whether these two recognition
sites function independently, synergistically, or competitively. Experimental evidence has
suggested that fibrinogen binding to the RGD-type integrin αIIbβ3 occurs exclusively through
the synergistic γ 400-411 sequence, thus questioning the functional role of the RGD
recognition site. Here we have investigated the respective role of the fibrinogen γ 400-411 …
site for ligand binding and signaling, although it is still unclear whether these two recognition
sites function independently, synergistically, or competitively. Experimental evidence has
suggested that fibrinogen binding to the RGD-type integrin αIIbβ3 occurs exclusively through
the synergistic γ 400-411 sequence, thus questioning the functional role of the RGD
recognition site. Here we have investigated the respective role of the fibrinogen γ 400-411 …
