Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
K Le Blanc, I Rasmusson, B Sundberg, C Götherström… - The Lancet, 2004 - thelancet.com
K Le Blanc, I Rasmusson, B Sundberg, C Götherström, M Hassan, M Uzunel, O Ringdén
The Lancet, 2004•thelancet.comAdult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong
the rejection of mismatched skin grafts in animals. We transplanted haploidentical
mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-
versus-host disease of the gut and liver. Clinical response was striking. The patient is now
well after 1 year. We postulate that mesenchymal stem cells have a potent
immunosuppressive effect in vivo.
the rejection of mismatched skin grafts in animals. We transplanted haploidentical
mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-
versus-host disease of the gut and liver. Clinical response was striking. The patient is now
well after 1 year. We postulate that mesenchymal stem cells have a potent
immunosuppressive effect in vivo.
Summary
Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
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