Neural (stem) cell transplantation has been proposed as a means of cell replacement
therapy. Multipotential neural precursor cells (NPCs) that expand in floating spheres, and
are (partially) committed to a glial fate, showed excellent remyelinating properties in a focal,
chemically induced demyelinated lesion in the rat spinal cord. When transplanted into the
CNS of rodents with acute and chronic EAE the NPCs were attracted by the inflammatory
process to migrate exclusively into inflamed white matter but not into adjacent gray matter …