The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer
G Zogopoulous, H Rothenmund, A Eppel, C Ash… - Human genetics, 2007 - Springer
Human genetics, 2007•Springer
The P239S palladin variant has recently been suggested to play a role in hereditary
pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding
sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was
identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly
relative with pancreas cancer. We conclude that this variant does not appear to account for a
significant fraction of hereditary or early-onset pancreas cancer.
pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding
sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was
identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly
relative with pancreas cancer. We conclude that this variant does not appear to account for a
significant fraction of hereditary or early-onset pancreas cancer.
Abstract
The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.
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