[HTML][HTML] Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5
SK Lee, A Stack, E Katzowitsch, SI Aizawa… - Microbes and …, 2003 - Elsevier
Helicobacter pylori is a flagellated chronic pathogen, which colonizes the gastric mucus and
mucosal cell surfaces. Flagella and motility are essential for the survival of this bacterium in
the stomach environment. Flagellins of several bacterial species are potent activators of the
human innate immune system by binding to TOLL-like receptor 5 (TLR5). The possible role
of the two H. pylori flagellins FlaA and FlaB in stimulation of the innate immune system and
induction of IL-8 release by human gastric epithelial cells was investigated in this study …
mucosal cell surfaces. Flagella and motility are essential for the survival of this bacterium in
the stomach environment. Flagellins of several bacterial species are potent activators of the
human innate immune system by binding to TOLL-like receptor 5 (TLR5). The possible role
of the two H. pylori flagellins FlaA and FlaB in stimulation of the innate immune system and
induction of IL-8 release by human gastric epithelial cells was investigated in this study …
