[HTML][HTML] The CD20 calcium channel is localized to microvilli and constitutively associated with membrane rafts: antibody binding increases the affinity of the …
H Li, LM Ayer, MJ Polyak, CM Mutch, RJ Petrie… - Journal of Biological …, 2004 - ASBMB
CD20 is a B cell-specific membrane protein that functions in store-operated calcium entry
and serves as a useful target for antibody-mediated therapeutic depletion of B cells.
Antibody binding to CD20 induces a diversity of biological effects, some of which are
dependent on lipid rafts. Rafts are isolated as low density detergent-resistant membranes,
initially characterized using Triton X-100. We have previously reported that CD20 is soluble
in 1% Triton but that antibodies induce the association of CD20 with Triton-resistant rafts …
and serves as a useful target for antibody-mediated therapeutic depletion of B cells.
Antibody binding to CD20 induces a diversity of biological effects, some of which are
dependent on lipid rafts. Rafts are isolated as low density detergent-resistant membranes,
initially characterized using Triton X-100. We have previously reported that CD20 is soluble
in 1% Triton but that antibodies induce the association of CD20 with Triton-resistant rafts …