[HTML][HTML] Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator α-NAC and its coactivation potency
I Quélo, C Gauthier, GE Hannigan, S Dedhar… - Journal of Biological …, 2004 - ASBMB
Overexpression of the integrin-linked kinase (ILK) was shown to increase c-Jun-dependent
transcription. We now show that this effect of ILK involves the c-Jun transcriptional
coactivator, nascent polypeptide-associated complex and coactivator α (α-NAC). ILK
phosphorylated α-NAC on residue Ser-43 upon adhesion of cells to fibronectin. Co-
expression of constitutively active ILK with α-NAC led to the nuclear accumulation of the
coactivator. Conversely, α-NAC remained in the cytoplasm of cells transfected with a …
transcription. We now show that this effect of ILK involves the c-Jun transcriptional
coactivator, nascent polypeptide-associated complex and coactivator α (α-NAC). ILK
phosphorylated α-NAC on residue Ser-43 upon adhesion of cells to fibronectin. Co-
expression of constitutively active ILK with α-NAC led to the nuclear accumulation of the
coactivator. Conversely, α-NAC remained in the cytoplasm of cells transfected with a …
