Primary hepatocellular carcinoma (HCC) is one of the most common malignancies
worldwide. However, the viral-chemical etiology as well as molecular mechanisms of HCC
pathogenesis remains largely unknown. Recent studies in our laboratory have identified
several potential factors that may contribute to the pathogenesis of HCC. Oxidative stress
and chronic inflammation have been linked to an increased risk of liver cancer. For example,
oxyradical overload diseases such as Wilson disease and hemochromatosis result in the …