Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice
A Sugihara, T Tsujimura, Y Fujita, Y Nakata… - Journal of …, 1999 - Elsevier
Background/Aims: Several studies have suggested that mast cells participate in the
development of liver fibrosis in rodent models. In this study mast cell-deficient mutant Ws/Ws
rats and W/Wv mice were used to examine whether mast cells are involved in the
development of liver fibrosis. Methods: Liver fibrosis was induced in rats by bile duct
resection (BDR), and by intraperitoneal injections of carbon tetrachloride (CCl4) or porcine
serum, and in mice by intragastric administrations of CCl4, and BDR. The degree of fibrosis …
development of liver fibrosis in rodent models. In this study mast cell-deficient mutant Ws/Ws
rats and W/Wv mice were used to examine whether mast cells are involved in the
development of liver fibrosis. Methods: Liver fibrosis was induced in rats by bile duct
resection (BDR), and by intraperitoneal injections of carbon tetrachloride (CCl4) or porcine
serum, and in mice by intragastric administrations of CCl4, and BDR. The degree of fibrosis …
