Association between genetic polymorphism of angiotensin-converting enzyme gene and Parkinson's disease

JJ Lin, KC Yueh, DC Chang, SZ Lin - Journal of the neurological sciences, 2002 - Elsevier
This study was designed to investigate the hypothesis that deletion/insertion (D/I)
polymorphism of the angiotensin-converting enzyme (ACE) gene may contribute to
increased risk of Parkinson's disease (PD). A case-control study was carried out to examine
the association between the ACE genotype and the allele frequency in 127 sporadic PD
patients compared with 198 healthy controls. The frequency of the homozygote DD
genotype of the ACE gene was significantly increased in patients with PD than in the …