In vitro production of tumor necrosis factor by murine splenic macrophages stimulated with mannoprotein constituents of Candida albicans cell wall
Mannoprotein components from Candida albicans were investigated for their ability to
induce production of tumor necrosis factor (TNF) by cultured splenocytes from naive or
Candida-infected mice. Two chromatographically separated mannoproteins preparations,
designated F1 and F2, were as able as the heat-inactivated Candida cells to induce the
production of TNF from splenocytes of naive animals. In addition, they caused a significant
augmentation of basic TNF secretion by splenocytes of Candida-infected animals …
induce production of tumor necrosis factor (TNF) by cultured splenocytes from naive or
Candida-infected mice. Two chromatographically separated mannoproteins preparations,
designated F1 and F2, were as able as the heat-inactivated Candida cells to induce the
production of TNF from splenocytes of naive animals. In addition, they caused a significant
augmentation of basic TNF secretion by splenocytes of Candida-infected animals …