Neuregulins: functions, forms, and signaling strategies
DL Falls - The EGF Receptor Family, 2003 - Elsevier
Publisher Summary This chapter focuses on neuregulins (NRGs) that are the signaling
proteins that mediate cell–cell interactions in the nervous system, heart, breast, and other
organ systems. Signaling from an NRG-producing cell to an NRG-responsive cell involves
the binding of NRG to the extracellular domain of the receptor tyrosine kinases ErbB3 or
ErbB4, which leads to the formation of ErbB homo-or heterodimers (often including ErbB2),
which in turn activates intracellular signaling pathways leading to cellular responses that …
proteins that mediate cell–cell interactions in the nervous system, heart, breast, and other
organ systems. Signaling from an NRG-producing cell to an NRG-responsive cell involves
the binding of NRG to the extracellular domain of the receptor tyrosine kinases ErbB3 or
ErbB4, which leads to the formation of ErbB homo-or heterodimers (often including ErbB2),
which in turn activates intracellular signaling pathways leading to cellular responses that …
