Human immunity to M. tuberculosis: T cell subsets and antigen processing
WH Boom, DH Canaday, SA Fulton, AJ Gehring… - Tuberculosis, 2003 - Elsevier
A hallmark of M. tuberculosis infection is the ability of most (90–95%) healthy adults to
control infection through acquired immunity, in which antigen specific T cells and
macrophages arrest growth of M. tuberculosis bacilli and maintain control over persistent
bacilli. In addition to CD4+ T cells, other T cell subsets such as, γδ, CD8+ and CD1-restricted
T cells have roles in the immune response to M. tuberculosis. A diverse T cell response
allows the host to recognize a wider range of mycobacterial antigens presented by different …
control infection through acquired immunity, in which antigen specific T cells and
macrophages arrest growth of M. tuberculosis bacilli and maintain control over persistent
bacilli. In addition to CD4+ T cells, other T cell subsets such as, γδ, CD8+ and CD1-restricted
T cells have roles in the immune response to M. tuberculosis. A diverse T cell response
allows the host to recognize a wider range of mycobacterial antigens presented by different …
