Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model
Proceedings of the National Academy of Sciences, 2003•National Acad Sciences
To determine whether Akt activation was sufficient for the transformation of normal prostate
epithelial cells, m urine p rostate restricted A kt k inase activity was generated in t ransgenic
mice (MPAKT mice). Akt expression led to p70S6K activation, prostatic intraepithelial
neoplasia (PIN), and bladder obstruction. mRNA expression profiles from MPAKT ventral
prostate revealed similarities to human cancer and an angiogenic signature that included
three angiogenin family members, one of which was found elevated in the plasma of men …
epithelial cells, m urine p rostate restricted A kt k inase activity was generated in t ransgenic
mice (MPAKT mice). Akt expression led to p70S6K activation, prostatic intraepithelial
neoplasia (PIN), and bladder obstruction. mRNA expression profiles from MPAKT ventral
prostate revealed similarities to human cancer and an angiogenic signature that included
three angiogenin family members, one of which was found elevated in the plasma of men …
To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, murine prostate restricted Akt kinase activity was generated in transgenic mice (MPAKT mice). Akt expression led to p70S6K activation, prostatic intraepithelial neoplasia (PIN), and bladder obstruction. mRNA expression profiles from MPAKT ventral prostate revealed similarities to human cancer and an angiogenic signature that included three angiogenin family members, one of which was found elevated in the plasma of men with prostate cancer. Thus, the MPAKT model may be useful in studying the role of Akt in prostate epithelial cell transformation and in the discovery of molecular markers relevant to human disease.
National Acad Sciences
