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SC Harrison - Cell, 2003 - cell.com
SC Harrison
Cell, 2003•cell.comThe modularity of protein architecture and the diversity of protein domains hint at a vast
combinatorial richness. But evolution appears to have been relatively conservative about
selecting new combinations. When a particular grouping of domains within a polypeptide
chain can perform a concerted function, that combination tends to reappear in multiple
genomic contexts. In other words, once a molecular solution to a functional problem has
emerged, it is reused rather than reinvented.
combinatorial richness. But evolution appears to have been relatively conservative about
selecting new combinations. When a particular grouping of domains within a polypeptide
chain can perform a concerted function, that combination tends to reappear in multiple
genomic contexts. In other words, once a molecular solution to a functional problem has
emerged, it is reused rather than reinvented.
Abstract
The modularity of protein architecture and the diversity of protein domains hint at a vast combinatorial richness. But evolution appears to have been relatively conservative about selecting new combinations. When a particular grouping of domains within a polypeptide chain can perform a concerted function, that combination tends to reappear in multiple genomic contexts. In other words, once a molecular solution to a functional problem has emerged, it is reused rather than reinvented.
cell.com
