Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white …
UH Rudofsky, BD Evans, SL Balaban… - … ; a journal of technical …, 1993 - europepmc.org
UH Rudofsky, BD Evans, SL Balaban, VD Mottironi, AE Gabrielsen
Laboratory investigation; a journal of technical methods and pathology, 1993•europepmc.orgBackground F1 hybrids of New Zealand Black (NZB) and New Zealand White (NZW) mice
develop autoimmune glomerulonephritis resembling human lupus nephritis. Susceptibility to
this complex autoimmune syndrome in humans and mice has been linked to genes mapping
in or near the major histocompatibility complex that govern immune responses and levels of
certain complement components. Previous studies showed that both parental strains
contribute major histocompatibility complex-linked genes that are important for disease of …
develop autoimmune glomerulonephritis resembling human lupus nephritis. Susceptibility to
this complex autoimmune syndrome in humans and mice has been linked to genes mapping
in or near the major histocompatibility complex that govern immune responses and levels of
certain complement components. Previous studies showed that both parental strains
contribute major histocompatibility complex-linked genes that are important for disease of …
Background
F1 hybrids of New Zealand Black (NZB) and New Zealand White (NZW) mice develop autoimmune glomerulonephritis resembling human lupus nephritis. Susceptibility to this complex autoimmune syndrome in humans and mice has been linked to genes mapping in or near the major histocompatibility complex that govern immune responses and levels of certain complement components. Previous studies showed that both parental strains contribute major histocompatibility complex-linked genes that are important for disease of the F1 hybrid.
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