Autoimmune hemolytic anemia (AIHA) is a hematologic disorder that is rarely seen in infants
and young children. Most cases are associated with viral or bacterial infection, but the
immunologic events leading to hemolysis are poorly understood. We describe two infants
with severe cytomegalovirus (CMV)-associated warm antibody AIHA. One case was
immunohematologically analyzed and showed suggestive evidence that endogenous anti-
CMV IgG antibodies were the pathogenic antibodies leading to hemolysis, implicating a …