Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice
J Węgiel, HM Wiśniewski, J Dziewiątkowski… - Brain research, 1998 - Elsevier
J Węgiel, HM Wiśniewski, J Dziewiątkowski, M Tarnawski, R Kozielski, E Trenkner…
Brain research, 1998•ElsevierThe numerical density of microglial cells is reduced by 47% in the corpus callosum, by 37%
in the parietal cortex and by 34% in the frontal cortex of mice mutant at the op locus which
are totally devoid of colony stimulating factor-1 (CSF-1), the major growth factor for
macrophages. Moreover, microglia in the frontal cortex of the op/op mice are smaller and
have shorter cytoplasmic processes compared to control mice. Study suggests that CSF-1
plays a role in vivo in the formation and maturation of microglia and has little or no effect on …
in the parietal cortex and by 34% in the frontal cortex of mice mutant at the op locus which
are totally devoid of colony stimulating factor-1 (CSF-1), the major growth factor for
macrophages. Moreover, microglia in the frontal cortex of the op/op mice are smaller and
have shorter cytoplasmic processes compared to control mice. Study suggests that CSF-1
plays a role in vivo in the formation and maturation of microglia and has little or no effect on …
The numerical density of microglial cells is reduced by 47% in the corpus callosum, by 37% in the parietal cortex and by 34% in the frontal cortex of mice mutant at the op locus which are totally devoid of colony stimulating factor-1 (CSF-1), the major growth factor for macrophages. Moreover, microglia in the frontal cortex of the op/op mice are smaller and have shorter cytoplasmic processes compared to control mice. Study suggests that CSF-1 plays a role in vivo in the formation and maturation of microglia and has little or no effect on perivascular cells.
Elsevier
