TRP ion channels in the nervous system
MM Moran, H Xu, DE Clapham - Current opinion in neurobiology, 2004 - Elsevier
MM Moran, H Xu, DE Clapham
Current opinion in neurobiology, 2004•ElsevierThe transient receptor potential (TRP) superfamily comprises a group of non-selective cation
channels that sense and respond to changes in their local environments. TRP channels are
found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins
organized into six families: classical (TRPC), vanilloid (TRPV), melastatin (TRPM),
muclopins (TRPML), polycystin (TRPP), and ANKTM1 (TRPA). In the peripheral nervous
system, stimuli including temperature, pressure, inflammatory agents, and receptor …
channels that sense and respond to changes in their local environments. TRP channels are
found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins
organized into six families: classical (TRPC), vanilloid (TRPV), melastatin (TRPM),
muclopins (TRPML), polycystin (TRPP), and ANKTM1 (TRPA). In the peripheral nervous
system, stimuli including temperature, pressure, inflammatory agents, and receptor …
The transient receptor potential (TRP) superfamily comprises a group of non-selective cation channels that sense and respond to changes in their local environments. TRP channels are found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins organized into six families: classical (TRPC), vanilloid (TRPV), melastatin (TRPM), muclopins (TRPML), polycystin (TRPP), and ANKTM1 (TRPA). In the peripheral nervous system, stimuli including temperature, pressure, inflammatory agents, and receptor activation effect TRP-mediated responses. In the central nervous system, TRPs participate in neurite outgrowth, receptor signalling and excitotoxic cell death resulting from anoxia. TRP channels are emerging as essential cellular switches that allow animals to respond to their environments.
Elsevier
