Lumbar 5 ventral root transection-induced upregulation of nerve growth factor in sensory neurons and their target tissues: a mechanism in neuropathic pain
We have previously demonstrated that profound and persistent neuropathic pain as
displayed by mechanical and cold allodynia and thermal hyperalgesia can be produced by
a lumbar 5 ventral root transection (L5 VRT) model in adult rats in which only the motor
nerve fibers were injured without axotomy of sensory neurons. However, the underlying
mechanisms remain to be determined. In this study, by examining its changes in expression
and by inhibiting its functions using a neutralizing antibody, we have investigated whether …
displayed by mechanical and cold allodynia and thermal hyperalgesia can be produced by
a lumbar 5 ventral root transection (L5 VRT) model in adult rats in which only the motor
nerve fibers were injured without axotomy of sensory neurons. However, the underlying
mechanisms remain to be determined. In this study, by examining its changes in expression
and by inhibiting its functions using a neutralizing antibody, we have investigated whether …
