Human α-defensin 1 (HNP-1) inhibits adenoviral infection in vitro
A Bastian, H Schäfer - Regulatory peptides, 2001 - Elsevier
Adenoviral gene transfer is a promising tool for direct treatment of cystic fibrosis by local
application of the CFTR-gene via the airway. However, various host defense mechanisms
reduce the adenoviral infectivity and hereby the success of adenoviral transduction. Twenty-
eight of 62 BALs from various patients exerted strong inhibition of adenoviral infection of 293
cells. This soluble activity could be attributed to larger peptides rather than to small
molecules. Beside immunoglobulins, certain epithelial cell-derived anti-microbial …
application of the CFTR-gene via the airway. However, various host defense mechanisms
reduce the adenoviral infectivity and hereby the success of adenoviral transduction. Twenty-
eight of 62 BALs from various patients exerted strong inhibition of adenoviral infection of 293
cells. This soluble activity could be attributed to larger peptides rather than to small
molecules. Beside immunoglobulins, certain epithelial cell-derived anti-microbial …
