Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children
JQ He, M Chan-Yeung, AB Becker, H Dimich-Ward… - Genes & …, 2003 - nature.com
JQ He, M Chan-Yeung, AB Becker, H Dimich-Ward, AC Ferguson, J Manfreda, WTA Watson…
Genes & Immunity, 2003•nature.comWe studied a cohort containing 368 children at high risk of developing atopy and atopic
disorders and 540 parents of those children to investigate whether the IL13 Arg130Gln and
C− 1112 T polymorphisms were associated with these outcomes. We also investigated
whether haplotypes consisting of any two polymorphisms of IL13 Arg130Gln, IL13 C− 1112
T and IL4 C− 589 T were associated with these phenotypes. In 288 white children, the IL13
130Gln allele was associated with atopy (RR= 1.9, P= 0.047), and with atopic dermatitis …
disorders and 540 parents of those children to investigate whether the IL13 Arg130Gln and
C− 1112 T polymorphisms were associated with these outcomes. We also investigated
whether haplotypes consisting of any two polymorphisms of IL13 Arg130Gln, IL13 C− 1112
T and IL4 C− 589 T were associated with these phenotypes. In 288 white children, the IL13
130Gln allele was associated with atopy (RR= 1.9, P= 0.047), and with atopic dermatitis …
Abstract
We studied a cohort containing 368 children at high risk of developing atopy and atopic disorders and 540 parents of those children to investigate whether the IL13 Arg130Gln and C− 1112 T polymorphisms were associated with these outcomes. We also investigated whether haplotypes consisting of any two polymorphisms of IL13 Arg130Gln, IL13 C− 1112 T and IL4 C− 589 T were associated with these phenotypes. In 288 white children, the IL13 130Gln allele was associated with atopy (RR= 1.9, P= 0.047), and with atopic dermatitis (RR= 2.5, P= 0.014). The associations were confirmed using a family-based test of association (P= 0.027 and 0.030, respectively) in all subjects. In white subjects there were associations of haplotypes consisting of IL13 Arg130Gln and IL4 C− 589 T with atopic dermatitis (P= 0.006) and with atopy (P= 0.009). Our data suggest that the IL13 Arg130Gln polymorphism and haplotypes consisting of IL13 Arg130Gln and IL4 C− 589 T were associated with the development of atopy and atopic dermatitis at 24 months of age.
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