Paraventricular hypothalamic α-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects
MM Wirth, PK Olszewski, C Yu, AS Levine, SQ Giraudo - Peptides, 2001 - Elsevier
α-Melanocyte-stimulating hormone (α-MSH) appears to play a tonic inhibitory role in feeding
and energy storage. MTII, a specific synthetic MC3-R/MC4-R agonist, has similar effects on
feeding in rats. The current studies demonstrate that PVN administration of α-MSH or MTII
decreases nocturnal and NPY-stimulated food intake without causing aversive effects. Co-
administration with NPY of 600 pmol α-MSH or 1 pmol MTII into the PVN caused a significant
decrease in NPY-induced feeding. PVN administration of MTII or α-MSH at doses effective to …
and energy storage. MTII, a specific synthetic MC3-R/MC4-R agonist, has similar effects on
feeding in rats. The current studies demonstrate that PVN administration of α-MSH or MTII
decreases nocturnal and NPY-stimulated food intake without causing aversive effects. Co-
administration with NPY of 600 pmol α-MSH or 1 pmol MTII into the PVN caused a significant
decrease in NPY-induced feeding. PVN administration of MTII or α-MSH at doses effective to …
