[HTML][HTML] Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart
H Toko, W Zhu, E Takimoto, I Shiojima, Y Hiroi… - Journal of Biological …, 2002 - ASBMB
Csx/Nkx2-5, which is essential for cardiac development of the embryo, is abundantly
expressed in the adult heart. We here examined the role ofCsx/Nkx2-5 in the adult heart
using two kinds of transgenic mice. Transgenic mice that overexpress a dominant negative
mutant of Csx/Nkx2-5 (DN-TG mice) showed degeneration of cardiac myocytes and
impairment of cardiac function. Doxorubicin induced more marked cardiac dysfunction in DN-
TG mice and less in transgenic mice that overexpress wild typeCsx/Nkx2-5 (WT-TG mice) …
expressed in the adult heart. We here examined the role ofCsx/Nkx2-5 in the adult heart
using two kinds of transgenic mice. Transgenic mice that overexpress a dominant negative
mutant of Csx/Nkx2-5 (DN-TG mice) showed degeneration of cardiac myocytes and
impairment of cardiac function. Doxorubicin induced more marked cardiac dysfunction in DN-
TG mice and less in transgenic mice that overexpress wild typeCsx/Nkx2-5 (WT-TG mice) …
