[HTML][HTML] Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates: chemical aspects involved in the balance between …
DA Wink, JA Cook, SY Kim, Y Vodovotz… - Journal of Biological …, 1997 - ASBMB
Thiol-containing proteins are key to numerous cellular processes, and their functions can be
modified by thiol nitrosation or oxidation. Nitrosation reactions are quenched by O 2·¯, while
the oxidation chemistry mediated by peroxynitrite is quenched by excess flux of either NO or
O 2·¯. A solution of glutathione (GSH), a model thiol-containing tripeptide, exclusively
yielded S-nitrosoglutathione when exposed to the NO donor, Et 2 NN (O) NONa. However,
when xanthine oxidase was added to the same mixture, the yield of S-nitrosoglutathione …
modified by thiol nitrosation or oxidation. Nitrosation reactions are quenched by O 2·¯, while
the oxidation chemistry mediated by peroxynitrite is quenched by excess flux of either NO or
O 2·¯. A solution of glutathione (GSH), a model thiol-containing tripeptide, exclusively
yielded S-nitrosoglutathione when exposed to the NO donor, Et 2 NN (O) NONa. However,
when xanthine oxidase was added to the same mixture, the yield of S-nitrosoglutathione …
