Syndet, an adipocyte target SNARE involved in the insulin-induced translocation of GLUT4 to the cell surface
S Rea, LB Martin, S McIntosh, SL Macaulay… - Journal of Biological …, 1998 - ASBMB
In adipocytes, insulin stimulates the translocation of the glucose transporter, GLUT4, from an
intracellular storage compartment to the cell surface. Substantial evidence exists to suggest
that in the basal state GLUT4 resides in discrete storage vesicles. A direct interaction of
GLUT4 storage vesicles with the plasma membrane has been implicated because the v-
SNARE, vesicle-associated membrane protein-2 (VAMP2), appears to be a specific
component of these vesicles. In the present study we sought to identify the cognate target …
intracellular storage compartment to the cell surface. Substantial evidence exists to suggest
that in the basal state GLUT4 resides in discrete storage vesicles. A direct interaction of
GLUT4 storage vesicles with the plasma membrane has been implicated because the v-
SNARE, vesicle-associated membrane protein-2 (VAMP2), appears to be a specific
component of these vesicles. In the present study we sought to identify the cognate target …
