Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections
C Weidenmaier, JF Kokai-Kun, SA Kristian… - Nature medicine, 2004 - nature.com
C Weidenmaier, JF Kokai-Kun, SA Kristian, T Chanturiya, H Kalbacher, M Gross…
Nature medicine, 2004•nature.comColonization of the anterior nares in∼ 37% of the population is a major risk factor for severe
Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface-
exposed staphylococcal polymer, is essential for nasal colonization and mediates
interaction with human nasal epithelial cells. WTA-deficient mutants were impaired in their
adherence to nasal cells, and were completely unable to colonize cotton rat nares. This
study describes the first essential factor for S. aureus nasal colonization.
Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface-
exposed staphylococcal polymer, is essential for nasal colonization and mediates
interaction with human nasal epithelial cells. WTA-deficient mutants were impaired in their
adherence to nasal cells, and were completely unable to colonize cotton rat nares. This
study describes the first essential factor for S. aureus nasal colonization.
Abstract
Colonization of the anterior nares in ∼37% of the population is a major risk factor for severe Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface-exposed staphylococcal polymer, is essential for nasal colonization and mediates interaction with human nasal epithelial cells. WTA-deficient mutants were impaired in their adherence to nasal cells, and were completely unable to colonize cotton rat nares. This study describes the first essential factor for S. aureus nasal colonization.
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