Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers
JJL Jacobs, P Keblusek, E Robanus-Maandag… - Nature …, 2000 - nature.com
JJL Jacobs, P Keblusek, E Robanus-Maandag, P Kristel, M Lingbeek, PM Nederlof…
Nature genetics, 2000•nature.comTo identify new immortalizing genes with potential roles in tumorigenesis, we performed a
genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts
deficient for the oncogene Bmi1. We identified the T-box member TBX2 as a potent
immortalizing gene that acts by downregulating Cdkn2a (p19 ARF). TBX2 represses the
Cdkn2a (p19 ARF) promoter and attenuates E2F1, Myc or HRAS-mediated induction of
Cdkn2a (p19 ARF). We found TBX2 to be amplified in a subset of primary human breast …
genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts
deficient for the oncogene Bmi1. We identified the T-box member TBX2 as a potent
immortalizing gene that acts by downregulating Cdkn2a (p19 ARF). TBX2 represses the
Cdkn2a (p19 ARF) promoter and attenuates E2F1, Myc or HRAS-mediated induction of
Cdkn2a (p19 ARF). We found TBX2 to be amplified in a subset of primary human breast …
Abstract
To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts deficient for the oncogene Bmi1. We identified the T-box member TBX2 as a potent immortalizing gene that acts by downregulating Cdkn2a (p19 ARF). TBX2 represses the Cdkn2a (p19 ARF) promoter and attenuates E2F1, Myc or HRAS-mediated induction of Cdkn2a (p19 ARF). We found TBX2 to be amplified in a subset of primary human breast cancers, indicating that it might contribute to breast cancer development.
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