Nitric oxide and endothelin in the development of cardiac allograft vasculopathy. Potential targets for therapeutic interventions
Z Liu, SM Wildhirt, S Weismüller, C Schulze, N Conrad… - Atherosclerosis, 1998 - Elsevier
Extensive research has been carried out in recent years to discover the potential risk factors
contributing to cardiac allograft atherogenesis. Injury to endothelial cells has been regarded
as an important early mechanism in the development of transplant atherosclerosis; it leads
to the manifestation of epicardial and microvascular endothelial dysfunction and
development of intimal hyperplasia. Moreover, continuous minor endothelial cell damage
contributes to endothelial dysfunction which reflects one of the first measurable steps in the …
contributing to cardiac allograft atherogenesis. Injury to endothelial cells has been regarded
as an important early mechanism in the development of transplant atherosclerosis; it leads
to the manifestation of epicardial and microvascular endothelial dysfunction and
development of intimal hyperplasia. Moreover, continuous minor endothelial cell damage
contributes to endothelial dysfunction which reflects one of the first measurable steps in the …
