Cell-cell contacts are essential for morphogenesis and tissue function and play a vital role in
mediating endothelial cohesion within the vascular system during vessel growth and
organization. We identified a novel junctional adhesion molecule, named JAM-2, by a
selective RNA display method, which allowed identification of transcripts encoding
immunoglobulin superfamily molecules regulated during coculture of endothelial cells with
tumor cells. The JAM-2 transcript is highly expressed during embryogenesis and is detected …