[HTML][HTML] Influence of peroxisome proliferator-activated receptor α agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48
D Lindén, K Lindberg, J Oscarsson, C Claesson… - Journal of Biological …, 2002 - ASBMB
The peroxisome proliferator-activated receptor (PPAR) α agonist WY 14,643 increased the
secretion of apolipoprotein (apo) B-100, but not that of apoB-48, and decreased triglyceride
biosynthesis and secretion from primary rat hepatocytes. These effects resulted in
decreased secretion of apoB-100-very low density lipoprotein (VLDL) and an increased
secretion of apoB-100 on low density lipoproteins/intermediate density lipoproteins. ApoB-
48-VLDL was also replaced by more dense particles. The proteasomal inhibitor lactacystin …
secretion of apolipoprotein (apo) B-100, but not that of apoB-48, and decreased triglyceride
biosynthesis and secretion from primary rat hepatocytes. These effects resulted in
decreased secretion of apoB-100-very low density lipoprotein (VLDL) and an increased
secretion of apoB-100 on low density lipoproteins/intermediate density lipoproteins. ApoB-
48-VLDL was also replaced by more dense particles. The proteasomal inhibitor lactacystin …
