[HTML][HTML] Myristic acid increases dense lipoprotein secretion by inhibiting apoB degradation and triglyceride recruitment
E Kummrow, MM Hussain, M Pan, JB Marsh… - Journal of lipid …, 2002 - ASBMB
Fatty acids of varying lengths and saturation differentially affect plasma apolipoprotein B-100
(apoB-100) levels. To identify mechanisms at the level of production, rat hepatoma cells,
McA-RH7777, were incubated with [35 S] methionine and either fatty acid-BSA complexes or
BSA alone. There were increases in labeled apoB-100 secretion with saturated fatty acids
palmitic and myristic (MA)(153±20% and 165±11%, respectively, relative to BSA). Incubation
with polyunsaturated docosahexaenoic acid (DHA) decreased secretion to 26±2.0%, while …
(apoB-100) levels. To identify mechanisms at the level of production, rat hepatoma cells,
McA-RH7777, were incubated with [35 S] methionine and either fatty acid-BSA complexes or
BSA alone. There were increases in labeled apoB-100 secretion with saturated fatty acids
palmitic and myristic (MA)(153±20% and 165±11%, respectively, relative to BSA). Incubation
with polyunsaturated docosahexaenoic acid (DHA) decreased secretion to 26±2.0%, while …
