[HTML][HTML] Cyclooxygenases-1 and− 2 of Endothelial Cells Utilize Exogenous or Endogenous Arachidonic Acid for Transcellular Production of Thromboxane (∗)
S Karim, A Habib, S Lévy-Toledano… - Journal of Biological …, 1996 - ASBMB
The presence of prostaglandin (PG) H 2 in the supernatant of human umbilical vein
endothelial cells (HUVEC) stimulated by thrombin restores the capacity of aspirin-treated
platelets to generate thromboxane (TX) B 2. Induction of cyclooxygenase-2 (Cox-2) by
interleukin (IL)-1α or a phorbol ester increases this formation. HUVEC treated with aspirin
lost their capacity to generate PGs but recovery occurred after 3-or 6-h induction of Cox-2
with phorbol ester or IL-1α. Enzyme activity of the newly synthesized Cox-2 in aspirin-treated …
endothelial cells (HUVEC) stimulated by thrombin restores the capacity of aspirin-treated
platelets to generate thromboxane (TX) B 2. Induction of cyclooxygenase-2 (Cox-2) by
interleukin (IL)-1α or a phorbol ester increases this formation. HUVEC treated with aspirin
lost their capacity to generate PGs but recovery occurred after 3-or 6-h induction of Cox-2
with phorbol ester or IL-1α. Enzyme activity of the newly synthesized Cox-2 in aspirin-treated …
