[HTML][HTML] The triple threat to nascent apolipoprotein B: evidence for multiple, distinct degradative pathways
EA Fisher, M Pan, X Chen, X Wu, H Wang… - Journal of Biological …, 2001 - ASBMB
We previously showed that Ω-3 fatty acids reduce secretion of apolipoprotein B (apoB) from
cultured hepatocytes by stimulating post-translational degradation. In this report, we now
characterize this process, particularly in regard to the two known processes that degrade
newly synthesized apoB, endoplasmic reticulum (ER)-associated degradation and re-uptake
from the cell surface. First, we found that Ω-3-induced degradation preferentially reduces the
secretion of large, assembled apoB-lipoprotein particles, and apoB polypeptide length is not …
cultured hepatocytes by stimulating post-translational degradation. In this report, we now
characterize this process, particularly in regard to the two known processes that degrade
newly synthesized apoB, endoplasmic reticulum (ER)-associated degradation and re-uptake
from the cell surface. First, we found that Ω-3-induced degradation preferentially reduces the
secretion of large, assembled apoB-lipoprotein particles, and apoB polypeptide length is not …
