[HTML][HTML] Notch activation suppresses fibroblast growth factor-dependent cellular transformation
D Small, D Kovalenko, R Soldi, A Mandinova… - Journal of Biological …, 2003 - ASBMB
Aberrant activations of the Notch and fibroblast growth factor receptor (FGFR) signaling
pathways have been correlated with neoplastic growth in humans and other mammals. Here
we report that the suppression of Notch signaling in NIH 3T3 cells by the expression of either
the extracellular domain of the Notch ligand Jagged1 or dominant-negative forms of Notch1
and Notch2 results in the appearance of an exaggerated fibroblast growth factor (FGF)-
dependent transformed phenotype characterized by anchorage-independent growth in soft …
pathways have been correlated with neoplastic growth in humans and other mammals. Here
we report that the suppression of Notch signaling in NIH 3T3 cells by the expression of either
the extracellular domain of the Notch ligand Jagged1 or dominant-negative forms of Notch1
and Notch2 results in the appearance of an exaggerated fibroblast growth factor (FGF)-
dependent transformed phenotype characterized by anchorage-independent growth in soft …
