An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro
AB Zimrin, MS Pepper, GA McMahon, F Nguyen… - Journal of Biological …, 1996 - ASBMB
Angiogenesis, or the formation of new blood vessels, plays a central role in a number of
physiologic and pathologic conditions, including wound healing, diabetic retinopathy, and
solid tumor growth, and endothelial cells can be induced to mimic this process in vitro. Using
a modification of the differential display method (Zimrin, AB, Villeponteau, B., and Maciag,
T.(1995) Biochem. Biophys. Res. Commun. 213, 630-638), we isolated the human homolog
of the Jagged ligand for the Notch receptor from human endothelial cells exposed to fibrin …
physiologic and pathologic conditions, including wound healing, diabetic retinopathy, and
solid tumor growth, and endothelial cells can be induced to mimic this process in vitro. Using
a modification of the differential display method (Zimrin, AB, Villeponteau, B., and Maciag,
T.(1995) Biochem. Biophys. Res. Commun. 213, 630-638), we isolated the human homolog
of the Jagged ligand for the Notch receptor from human endothelial cells exposed to fibrin …
