[HTML][HTML] S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro
CM Carreira, TM LaVallee, F Tarantini… - Journal of Biological …, 1998 - ASBMB
We have previously characterized the release of the signal peptide sequence-less fibroblast
growth factor (FGF) prototype, FGF-1, in vitro as a stress-induced pathway in which FGF-1 is
released as a latent homodimer with the p40 extravesicular domain of p65 synaptotagmin
(Syn)-1. To determine the biologic relevance of the FGF-1 release pathway in vivo, we
sought to resolve and characterize from ovine brain a purified fraction that contained both
FGF-1 and p40 Syn-1 and report that the brain-derived FGF-1: p40 Syn-1 aggregate is …
growth factor (FGF) prototype, FGF-1, in vitro as a stress-induced pathway in which FGF-1 is
released as a latent homodimer with the p40 extravesicular domain of p65 synaptotagmin
(Syn)-1. To determine the biologic relevance of the FGF-1 release pathway in vivo, we
sought to resolve and characterize from ovine brain a purified fraction that contained both
FGF-1 and p40 Syn-1 and report that the brain-derived FGF-1: p40 Syn-1 aggregate is …
