HLA associations with multiple sclerosis in the Canary Islands
F Coraddu, MP Reyes-Yanez, A Parra, J Gray… - Journal of …, 1998 - Elsevier
The study of small island populations has proved informative with respect to the
epidemiology and genetics of many complex traits including multiple sclerosis. The class II
major histocompatibility antigen DR15 is associated with multiple sclerosis in all groups
except Sardinians, where the primary association is with DR4. We compared HLA-DR and-
DQ allele frequencies in a representative sample of patients with multiple sclerosis from the
Canary Islands with appropriate controls. There was a significant association with DR15 …
epidemiology and genetics of many complex traits including multiple sclerosis. The class II
major histocompatibility antigen DR15 is associated with multiple sclerosis in all groups
except Sardinians, where the primary association is with DR4. We compared HLA-DR and-
DQ allele frequencies in a representative sample of patients with multiple sclerosis from the
Canary Islands with appropriate controls. There was a significant association with DR15 …