Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein
LJ Ausubel, KD Bieganowska, DA Hafler - Cellular immunology, 1999 - Elsevier
We have determined that certain altered peptide ligands (APLs) can induce T-cells specific
for the native peptide myelin basic protein (MBP) p85-99 to secrete Th2-type cytokines such
as IL-4 and IL-5 in the absence of significant Th1-type cytokines. However, it is not known
whether stimulation with APLs will activate autoreactive T cells or a distinct population of
cells. In the present study, 18 T-cell clones that reacted with either MBP p85-99 or one of
three APLs of the peptide substituted at TCR contact residues were generated. T-cells were …
for the native peptide myelin basic protein (MBP) p85-99 to secrete Th2-type cytokines such
as IL-4 and IL-5 in the absence of significant Th1-type cytokines. However, it is not known
whether stimulation with APLs will activate autoreactive T cells or a distinct population of
cells. In the present study, 18 T-cell clones that reacted with either MBP p85-99 or one of
three APLs of the peptide substituted at TCR contact residues were generated. T-cells were …