Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden
SJ Khoury, CRG Guttmann, EJ Orav, MJ Hohol… - Neurology, 1994 - AAN Enterprises
Neurology, 1994•AAN Enterprises
We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and
without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke
Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a
significant correlation between the change in EDSS or AI and the change in number of
lesions on MRI and between cumulative number of lesions on MRI and cumulative change
in EDSS or AI. Our findings support the validity of MRI as a measure of clinical activity and …
without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke
Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a
significant correlation between the change in EDSS or AI and the change in number of
lesions on MRI and between cumulative number of lesions on MRI and cumulative change
in EDSS or AI. Our findings support the validity of MRI as a measure of clinical activity and …
We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a significant correlation between the change in EDSS or AI and the change in number of lesions on MRI and between cumulative number of lesions on MRI and cumulative change in EDSS or AI. Our findings support the validity of MRI as a measure of clinical activity and potentially as an objective quantitative outcome measure for assessing response to therapy.
American Academy of Neurology