[HTML][HTML] Plasmin-induced migration of endothelial cells: a potential target for the anti-angiogenic action of angiostatin
T Tarui, M Majumdar, LA Miles, W Ruf… - Journal of Biological …, 2002 - ASBMB
Angiostatin, a plasminogen fragment containing 3–4 N-terminal kringle domains, is a potent
inhibitor of tumor-induced angiogenesis, but its mechanism of action is unclear. Angiostatin
is a ligand for integrin αvβ 3 but does not induce stress fiber formation upon integrin binding,
suggesting that angiostatin is a potential integrin antagonist. Plasmin, the parent molecule of
angiostatin and a major extracellular protease, induces platelet aggregation, migration of
peripheral blood monocytes, and release of arachidonate and leukotriene from several cell …
inhibitor of tumor-induced angiogenesis, but its mechanism of action is unclear. Angiostatin
is a ligand for integrin αvβ 3 but does not induce stress fiber formation upon integrin binding,
suggesting that angiostatin is a potential integrin antagonist. Plasmin, the parent molecule of
angiostatin and a major extracellular protease, induces platelet aggregation, migration of
peripheral blood monocytes, and release of arachidonate and leukotriene from several cell …