[HTML][HTML] Endothelial cell VE-cadherin functions as a receptor for the β15–42 sequence of fibrin

TL Bach, C Barsigian, CH Yaen, J Martinez - Journal of Biological …, 1998 - ASBMB
The contact of fibrin with the apical surface of human umbilical vein endothelial cells
(HUVEC) can induce capillary tube formation via the interaction of fibrin β15–42 with a
putative cell receptor (Chalupowicz, DG, Chowdhury, ZA, Bach, TL, Barsigian, C., and
Martinez, J.(1995) J. Cell Biol. 130, 207–215). To characterize this interaction, we studied
the binding of the thrombin-cleaved N-terminal disulfide knot of fibrin (NDSK II), a dimeric
fragment with exposed β15–42, to HUVEC in three separate assay systems. Time-course …