Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation
DJ Falcone, TA McCaffrey… - Journal of Biological …, 1993 - ASBMB
We have determined whether macrophage derived-foam cells, a prominent component of
the atherosclerotic lesion, express more urokinase-type plasminogen activator (uPA) and
whether their ability to generate plasmin stimulates the release of matrix-bound growth
factors. Steady state levels of uPA mRNA and both membrane and intracellular uPA
activities were significantly increased in foam cells. When cultured on cell-derived matrices
containing bound 125I-basic fibroblast growth factor (bFGF), both macrophage and foam …
the atherosclerotic lesion, express more urokinase-type plasminogen activator (uPA) and
whether their ability to generate plasmin stimulates the release of matrix-bound growth
factors. Steady state levels of uPA mRNA and both membrane and intracellular uPA
activities were significantly increased in foam cells. When cultured on cell-derived matrices
containing bound 125I-basic fibroblast growth factor (bFGF), both macrophage and foam …