VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death
B Li, W Xu, C Luo, D Gozal, R Liu - Molecular Brain Research, 2003 - Elsevier
The increased oxidative stress induced by mutant SOD1 is associated with motor neuron
degeneration in both human ALS and transgenic mice expressing mutant SOD1. Vascular
endothelial growth factor (VEGF) is neurotrophic and also protects from hypoxia-induced
neuronal injury. The potential role of VEGF in preventing mutant SOD1-mediated motor
neuron cell death was examined using a mouse NSC34 motor neuron-like cell culture
system. Infection with adenovirus containing mutant G93A-SOD1, but not vector control or …
degeneration in both human ALS and transgenic mice expressing mutant SOD1. Vascular
endothelial growth factor (VEGF) is neurotrophic and also protects from hypoxia-induced
neuronal injury. The potential role of VEGF in preventing mutant SOD1-mediated motor
neuron cell death was examined using a mouse NSC34 motor neuron-like cell culture
system. Infection with adenovirus containing mutant G93A-SOD1, but not vector control or …
