[HTML][HTML] Mitochondrial functional state in clonal pancreatic β-cells exposed to free fatty acids
V Koshkin, X Wang, PE Scherer, CB Chan… - Journal of Biological …, 2003 - ASBMB
Excessive free fatty acid (FFA) exposure represents a potentially important diabetogenic
condition that can impair insulin secretion from pancreatic β-cells. Because mitochondrial
oxidative phosphorylation is a main link between glucose metabolism and insulin secretion,
in the present work we investigated the effects of the FFA oleate (OE) on mitochondrial
function in the clonal pancreatic β-cell line, MIN6. Both the long term (72 h) and short term
(immediately after application) impact of OE exposure on β-cells was investigated. After 72 h …
condition that can impair insulin secretion from pancreatic β-cells. Because mitochondrial
oxidative phosphorylation is a main link between glucose metabolism and insulin secretion,
in the present work we investigated the effects of the FFA oleate (OE) on mitochondrial
function in the clonal pancreatic β-cell line, MIN6. Both the long term (72 h) and short term
(immediately after application) impact of OE exposure on β-cells was investigated. After 72 h …