[HTML][HTML] Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
M Jabůrek, M Vařecha, RE Gimeno, M Dembski… - Journal of Biological …, 1999 - ASBMB
Uncoupling protein 1 (UCP1) dissipates energy and generates heat by catalyzing back-flux
of protons into the mitochondrial matrix, probably by a fatty acid cycling mechanism. If the
newly discovered UCP2 and UCP3 function similarly, they will enhance peripheral energy
expenditure and are potential molecular targets for the treatment of obesity. We expressed
UCP2 and UCP3 in Escherichia coli and reconstituted the detergent-extracted proteins into
liposomes. Ion flux studies show that purified UCP2 and UCP3 behave identically to UCP1 …
of protons into the mitochondrial matrix, probably by a fatty acid cycling mechanism. If the
newly discovered UCP2 and UCP3 function similarly, they will enhance peripheral energy
expenditure and are potential molecular targets for the treatment of obesity. We expressed
UCP2 and UCP3 in Escherichia coli and reconstituted the detergent-extracted proteins into
liposomes. Ion flux studies show that purified UCP2 and UCP3 behave identically to UCP1 …