[HTML][HTML] Low Chloride Stimulation of Prostaglandin E2Release and Cyclooxygenase-2 Expression in a Mouse Macula Densa Cell Line
T Yang, JM Park, L Arend, Y Huang… - Journal of Biological …, 2000 - ASBMB
Reducing luminal NaCl concentration in the macula densa region of the nephron stimulates
renin secretion, and this response is blocked by a specific inhibitor of cyclooxygenase-2
(COX-2)(Traynor, TR, Smart, A., Briggs, JP, and Schnermann, J.(1999) Am. J. Physiol. Renal
Physiol. 277, F706–710). To study whether low NaCl activates COX-2 activity or expression
we clonally derived a macula densa cell line (MMDD1 cells) from SV-40 transgenic mice
using fluorescence-activated cell sorting of renal tubular cells labeled with segment-specific …
renin secretion, and this response is blocked by a specific inhibitor of cyclooxygenase-2
(COX-2)(Traynor, TR, Smart, A., Briggs, JP, and Schnermann, J.(1999) Am. J. Physiol. Renal
Physiol. 277, F706–710). To study whether low NaCl activates COX-2 activity or expression
we clonally derived a macula densa cell line (MMDD1 cells) from SV-40 transgenic mice
using fluorescence-activated cell sorting of renal tubular cells labeled with segment-specific …