Reversal of indomethacin-induced inhibition of tubuloglomerular feedback by prostaglandin infusion
J Schnermann, PC Weber - Prostaglandins, 1982 - Elsevier
Experiments were performed in rats to study the effect of infusion of PGI 2, PGE 2, and PGF
2α on tubuloglomerular feedback responses (ie the change of SNGFR in response to a
change of loop of Henle flow rate) in the presence and absence of simultaneous inhibition of
endogenous PG synthesis with indomethacin. Infusion of PGI 2 or PGE 2 at rates that did not
alter arterial blood pressure did not significantly modify the magnitude of feedback
responses (PGI 2) 8.5 μg/hr, PGE 2 85 μg/hr). Some inhibition of feedback responses was …
2α on tubuloglomerular feedback responses (ie the change of SNGFR in response to a
change of loop of Henle flow rate) in the presence and absence of simultaneous inhibition of
endogenous PG synthesis with indomethacin. Infusion of PGI 2 or PGE 2 at rates that did not
alter arterial blood pressure did not significantly modify the magnitude of feedback
responses (PGI 2) 8.5 μg/hr, PGE 2 85 μg/hr). Some inhibition of feedback responses was …