Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
P Li, H Allen, S Banerjee, S Franklin, L Herzog… - Cell, 1995 - Elsevier
P Li, H Allen, S Banerjee, S Franklin, L Herzog, C Johnston, J McDowell, M Paskind…
Cell, 1995•ElsevierIL-1β-converting enzyme (ICE) cleaves pro-1L-1β to generate mature IL-1β. ICE is
homologous to other proteins that have been implicated in apoptosis, including CED-3 and
Nedd-2/Ich-1. We generated ICE-deficient mice and observed that they are overtly normal
but have a major defect in the production of mature IL-1β after stimulation with
lipopolysaccharide. IL-1α production is also impaired. ICE-deficient mice are resistant to
endotoxic shock. Thymocytes and macrophages from the ICE-deficient animals undergo …
homologous to other proteins that have been implicated in apoptosis, including CED-3 and
Nedd-2/Ich-1. We generated ICE-deficient mice and observed that they are overtly normal
but have a major defect in the production of mature IL-1β after stimulation with
lipopolysaccharide. IL-1α production is also impaired. ICE-deficient mice are resistant to
endotoxic shock. Thymocytes and macrophages from the ICE-deficient animals undergo …
IL-1β-converting enzyme (ICE) cleaves pro-1L-1β to generate mature IL-1β. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/Ich-1. We generated ICE-deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL-1β after stimulation with lipopolysaccharide. IL-1α production is also impaired. ICE-deficient mice are resistant to endotoxic shock. Thymocytes and macrophages from the ICE-deficient animals undergo apoptosis normally. ICE therefore plays a dominant role in the generation of mature IL-1β, a previously unsuspected role in production of IL-1α, but has no autonomous function in apoptosis.
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