Free fatty acids—the link between obesity and insulin resistance
G Boden - Endocrine Practice, 2001 - Elsevier
Objective To present evidence that free fatty acids (FFA) are an important link between
obesity and insulin resistance. Methods The role of FFA in peripheral insulin resistance,
hepatic insulin resistance, insulin secretion, and type 2 diabetes is discussed. Results
Obesity is invariably associated with insulin resistance. In most obese subjects, plasma FFA
levels are increased. Physiologic increases in plasma FFA levels cause insulin resistance in
both diabetic and nondiabetic subjects by producing several metabolic defects:(1) FFA …
obesity and insulin resistance. Methods The role of FFA in peripheral insulin resistance,
hepatic insulin resistance, insulin secretion, and type 2 diabetes is discussed. Results
Obesity is invariably associated with insulin resistance. In most obese subjects, plasma FFA
levels are increased. Physiologic increases in plasma FFA levels cause insulin resistance in
both diabetic and nondiabetic subjects by producing several metabolic defects:(1) FFA …